详细信息
摘要
作者
：
霍勇 陈光亮 徐希平
文章题名
：
英文篇名 : Pharmacology and clinical evaluation of enalapril maleate and folic acid tablet
标识号
：
ISSN : 1003-3734 CN : 11-2850/R
中文关键词
：
马来酸依那普利叶酸片;高血压;同型半胱氨酸;药动学;药效学;临床研究
英文关键词
：
enalapril maleate and folic acid tablet;hypertension;homocysteine;pharmacokinetics;pharmacodynamics;clinical research
作者机构
：
北京大学第一医院;安徽医科大学生物医学研究所;深圳大学生物医药研究所
基金
：
安徽省十五攻关课题(02013056)
分类号
：
中图分类 : R96
引文
：
[1]陈光亮,霍勇,李建平,等.复方I类新药依那普利叶酸片创新思路[J].中国新药杂志,2009,18(17):1590-1593.
[2]胡大一,徐希平.有效控制“H型”高血压——预防脑卒中的新思路[J].中华内科杂志,2008,47(12):976-977.
[3]GRAHAMIM,DALY LE,REFSUMHM,et al.Plasma homocys-teine as a risk factor for vascular disease.The European Concert-ed Action Project[J].JAMA,1997,277(22):1775-1781.
[4]王拥军,刘力生,饶克勤,等.我国脑卒中预防策略思考:同时控制高血压和高同型半胱氨酸水平[J].中华医学杂志,2008,88(47):3316-3318.
[5]Homocysteine Lowering Trialists Collaboration.Dose-dependenteffects of folic acid on blood concentrations of homocysteine:ameta-analysis of the randomized trials[J].Am J Clin Nutr,2005,82(4):806-812.
[6]李建平,霍勇,刘平,等.马来酸依那普利叶酸片降压、降同型半胱氨酸的疗效和安全性[J].北京大学学报(医学版),2007,39(6):614-618.
[7]MAO G,HONG X,XING H,et al.Efficacy of folic acid and en-alapril combined therapy on reduction of blood pressure and plas-ma glucose:a multicenter,randomized,double-blind,parallel-controlled,clinical trial[J].Nutrition,2008,24(11-12):1088-1096.
[8]赵峰,李建平,王淑玉,等.高血压人群基线同型半胱氨酸水平对依那普利叶酸片降压及降同型半胱氨酸疗效的作用分析[J].中华医学杂志,2008,88(42):2957-2961.
[9]孙宁玲,秦献辉,李建平,等.依那普利叶酸片固定复方与依那普利和叶酸自由联合在H型高血压人群中降低同型半胱氨酸的疗效比较[J].中国新药杂志,2009,18(17):1635-1640.
[10]MARK SD,WANG W,FRAUMENI JF JR,et al.Lowered risksof hypertension and cerebrovascular disease after vitamin/mineralsupplementation:the Linxian nutrition intervention[J].Am JEpidemiol,1996,143(7):658-664.
[11]LONN E,YUSUF S,ARNOLD MJ,et al.Heart Outcomes Pre-vention Evaluation(HOPE)2 Investigators[J].NEngl J Med,2006,354(15):1567-1577.
[12]SAPOSNIK G,RAY JG,SHERIDAN P,et al.Homocysteine-lowering therapy and stroke risk,severity,and disability:addi-tional findings from the HOPE 2 trial[J].Stroke,2009,40(4):1365-1372.
[13]WANG X,QIN X,DEMIRTAS H,et al.Efficacy of folic acidsupplementation in stroke prevention:a meta-analysis[J].Lan-cet,2007,369(9576):1876-1882.
[14]The European Stroke Organisation(ESO)Executive Committeeand the ESO Writing Committee.Guidelines for management ofischaemic stroke and transient ischaemic attack 2008[J].Cere-brovasc Dis,2008,25(5):457-507.
[15]ALBERTCM,COOK NR,GAZIANO JM,et al.Effect of folicacid and B vitamins on risk of cardiovascular events and totalmortality among women at high risk for cardiovascular disease:arandomized trial[J].JAMA,2008,299(17):2027-2036.
[16]ZHAO D,LIU J,WANG W,et al.Epidemiological transition ofstroke in China:twenty-one-year observational study from the Si-no-MONICA-Beijing Project[J].Stroke,2008,39(6):1668-1674.
来源
：
中国新药杂志, Chinese Journal of New Drugs,2010,18
刊名
：
中国新药杂志 Chinese Journal of New Drugs
年
：
2010
期
：
18
页
：
14-17
页数
：
4
印刷页码
：
1633-1636
更新日期
：
2010-10-22
中文摘要
依那普利叶酸片是第一个批准用于治疗伴同型半胱氨酸升高的原发性高血压的药物,于2008年3月获得SFDA批准上市,其组方及配比获得国家发明专利。高血压与高同型半胱氨酸可能是导致我国脑卒中高发的最重要的两个危险因素。依那普利叶酸片较单用降压药进一步降低脑卒中风险25~37。文中综述了该药的创新思路、药动学、药效学、临床研究与不良反应。
英文摘要
[Enalapril maleate and folic acid tablet is the first novel combination drug approved by SFDA in 2008.Its indication is essential hypertension complicated with homocysteinemia.Hypertension and homocysteinemia are two critical independent risk factors for stroke.Enalapril maleate and folic acid tablets reduced the risk of stroke incidence by 25~37 more than the anti-hypertensive drug alone does.In this article,we introduced the innovation strategy of the enalapril maleate and folic acid tablet,and its pharmacokinetics,pharmacodynamics,clinical trial findings and adverse reactions.]
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